CORRELATION BETWEEN MACULAR AND IRIS AND MACULAR THICKNESS IN CONTROLLED VERSUS UNCONTROLLED DIABETIC PATIENTS

Document Type : Original articles: include clinical trials, interventional research, Basic researches and clinically relevant laboratory investigations

Authors

Ophthalmology dept., Faculty of Medicine, Sohag, Univ., Egypt

Abstract

Background: Diabetes mellitus (DM) can lead to ocular complications, including diabetic
retinopathy (DR) and macular edema. The current research compared iris thickness (IT) and central
macular thickness (CMT) between controlled and uncontrolled diabetic patients.
Methods: Sixty
patients participated in the cross-sectional study, aged ≥18 years with controlled (n=20) and
uncontrolled (n=20) DM, and non-diabetic controls (n=20). CMT and IT at1,2, and 3 millimeters
from the margin of the pupil were measured using optical coherence tomography (OCT) and
anterior segment imaging, respectively.
Results: Compared to the control group, both diabetic
groups had considerably decreased CMT (p < 0.001), but comparable between controlled and
uncontrolled diabetics. There were no discernible variations in IT between the groups regardless
of the distance. The results showed that CMT and IT had a significantly negative correlation with
diabetics under control at 2 mm (r = -0.569, p = 0.008), but not at other distances.
Conclusions:
Diabetic patients exhibited macular thinning regardless of glycemic control, while IT was
unaffected. Interestingly, lower CMT correlated with reduced IT at specific locations (IT2 and IT3)
in controlled diabetics, suggesting a potential relationship between these ocular parameters in
this population.


Keywords